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Office
Hours:
Dr.
Miriam Ziegler (Instructor, Course Coordinator) Dr. Roger Miesfeld (Instructor) Ms. Swapna Aravind (T.A.) Ms. Salma Kaochar (T.A.) Ms. Deboleena Sarkar (T.A.)
Mon and Wed, 3:50-5:15 pm, after class in ILC 120 and then in BioW 345A; or by appointment: 626-9388
zieglerm@u.arizona.edu
Thurs and Fri 11:00 am-12 noon, BioW 518;
or by appointment: 626-2343
rlm@u.arizona.edu
BioW 530, 621-5113
Wed and Thurs 9:00-10:00 a.m. in BioW 251A
swapnaa@email.arizona.edu
LSS 409, 621-9358
Fri 10:00-11:00 am and 1:00-2:00 pm in BioW 251A
salma@email.arizona.edu
Mon. 9:45-11:45 a.m. in BioW 251A
dsarkar@email.arizona.edu
Examinations:
Four one-hour examinations (100 points each) will be given as indicated on
the schedule. The last hour examination will be the last day of classes, for which the course has special permission from the Dean of Science
(3:00-3:50
p.m. Wed., May 7, 2008).
In addition, there will be four 10-min quizzes (20 points
each) during class. The exam and quiz format is based
on short answers and fill-in-the-blank type questions, with some calculations
and perhaps multiple choice questions on quizzes. Each quiz may cover
material to be discussed on the day of the quiz, i.e., preparation
for class, as well as questions from earlier lectures. One
quiz will be dropped, either one missed quiz or the lowest quiz score. There will be no make-up quizzes, and no excused absences
from the 10-min quizzes need to be documented by you unless you miss more
than one quiz, both absences being for excused reasons. In
this unusual circumstance, you should bring the documentation for both missed quizzes to Dr. Ziegler within 1 week after the second (excused) missed quiz.
Exams and exam
review/help sessions this semester are scheduled for the following
times:
HOUR EXAMS (all in ILC 120) |
REVIEW/HELP SESSIONS |
Mon. Feb. 11 (3:00-3:50 pm) |
Thurs Feb. 7: 4:00-5:00 pm, EDUC 211 |
Mon. Mar. 10 (3:00-3:50 pm) |
Thurs Mar. 6: 4:00-5:00 pm, Chavez 111 |
Mon. Apr. 14 (3:00-3:50 pm) |
Thurs Apr. 10: 4:00-5:00 pm, Chavez 111 |
Wed. May 7 (3:00-3:50 pm) |
Mon. May 5: 4:00-5:00 pm, ILC 120 |
The hour examinations must be taken at scheduled times. If possible, an examination
may be rescheduled for medical reasons, or death in the family, but only if
the emergency is documented by an appropriate letter. If a medical emergency
does arise, it is the student's responsibility to contact Dr. Ziegler
(course coordinator) by telephone or email prior to the start
of the examination to reschedule the exam for the
next day. (The
only exception would be for a student who also has an excused absence for
the day after the exam, but again, that requires discussion with Dr.
Ziegler.) The telephone is by far the most effective means of arranging
a time to reschedule an exam, so if you have to leave a voicemail message
or send an email, be sure to leave a telephone number where you can be reached.
IMPORTANT
NOTE ABOUT CALCULATORS:
The course requires a non-programmable scientific calculator that can do logs and natural logs (ln) for exams
and for some quizzes. Such calculators can be bought at discount stores for
less than $10; no sharing of calculators will be permitted during exams and quizzes.
Be sure you understand how to use the calculator (logs and antilogs) before
you bring it to an exam. No programmable calculators will be permitted during exams and quizzes, so please don't even ask!
Regrading
of Exams:
Requests for regrading of exam answers must be made in writing on your own
separate piece of paper attached to the exam and turned in to the instructor
in charge of that exam within three class periods (one week) after the return
of exams. DO NOT WRITE ON THE EXAM ITSELF. In your request, you should
explain why your answer is correct. The entire exam may be regraded when any regrading is requested.
Cheating:
Cheating will absolutely not be tolerated. The Student Code of Conduct may be found at http://w3.arizona.edu/~studpubs/policies/studcofc.htm. Anyone caught cheating will fail this course and be subject to disciplinary proceedings as prescribed by university policies, described at http://w3.arizona.edu/~studpubs/policies/studdisc.htm. Potential outcomes
from this include expulsion from the University. Changing your answer on a
test after it has been returned, and requesting a regrading of the exam, is
cheating. We will routinely photocopy 15-25% of the exams to discourage
this form of cheating, so don't do it!
Grades: Grades will be posted on D2L, accessed through http://www.d2l.arizona.edu, with student's Net ID and password.
The final grade will be determined based on the total points out of 460 points:
400 pts from 4 hour exams and 60 pts from the best 3 out of 4 10-min quizzes. Course grades on a total point basis out of 460 points will be curved
if necessary based on overall class performance, but the final course grade cut-offs
(minimum percentage grades required) for final grades of A, B, C, and D, respectively,
will be no higher than 90, 80, 70, 60%. Although an approximate letter grade distribution
will be posted for each exam, those posted letter grade distributions for
individual exams will be intended simply as general guidelines for
students to assess their ongoing performance in the class; we will not record
letter grades for individual exams and thus will not agonize over the posted "cut-offs" for each exam. Students are responsible for checking their grades on D2L
to confirm that their recorded exam and quiz scores are correct. Keep your copy
of each original graded exam and quiz until the end of the semester to
document any discrepancies.
Lecture Schedule
- Spring 2008 (tentative)
Lecture notes (password-protected) will be posted in general by the end of the day before the lecture.
NOTE:
Lecture schedule is tentative; revisions will be posted as needed.
Check announcements on website.
Print out PDFs of required background (review)
on logarithms and on concepts of
general chemistry, which includes sample problems and answers, to be sure you
are able to work with those concepts. See homepage or "What's New" for times and locations of 1st week general chem review.
Date |
Lecture |
Topic |
Instructor |
|
W - Jan 16 |
1 | Introduction, Properties of Water |
1
| Dr. Ziegler |
F - Jan 18 |
2 | Biological Thermodynamics |
pp. 11-14 & 208-210
| Dr. Ziegler |
M - Jan 21 |
MLK Holiday - NO CLASS |
|
||
W - Jan 23 |
3 | Amino Acids | 2, pp. 25-34 |
Dr. Ziegler |
F - Jan 25 |
4 | Peptides |
2, pp. 34-37
| Dr. Ziegler |
M - Jan 28 |
5 | Proteins, Secondary Structure |
2, pp. 37-45
| Dr. Ziegler |
W - Jan 30 |
6 | Proteins: Tertiary and Quaternary Structure |
2, pp. 44-53 pp. 61-62 | Dr. Ziegler |
F - Feb 1 |
7 | Proteins: Folding; Quiz 1 |
2, pp. 53-60
| Dr. Ziegler |
M - Feb 4 |
8 | Protein Function: Myoglobin and Hemoglobin 1 |
7, pp. 183-192
| Dr. Ziegler |
W - Feb 6 |
9 | Protein Function: Myoglobin and Hemoglobin 2 |
7, pp. 192-199
| Dr. Ziegler |
Th - Feb 7 |
Review/Help Session, 4:00-5:00, EDUC 211 |
Dr. Ziegler |
||
F - Feb 8 |
10 | Enzymes: Introduction |
8, pp. 205-216
| Dr. Ziegler |
M - Feb 11 |
EXAM 1 | Dr. Ziegler |
||
W - Feb 13 |
11 | Enzymes: Kinetics |
8, pp. 216-225
| Dr. Ziegler |
F - Feb 15 |
12 | Enzymes: Inhibition |
8, pp. 225-236
| Dr. Ziegler |
M - Feb 18 |
13 | Enzymes: Catalytic Strategies 1 (Wed. Feb. 14) |
9, pp. 241-254
| Dr. Ziegler |
W - Feb 20 |
14 | Enzymes: Catalytic Strategies 2 |
9, pp. 241-254
| Dr. Ziegler |
F - Feb 22 |
15 | Regulatory Strategies: Allosteric Regulation, Isozymes |
10, pp. 275-283
| Dr. Ziegler |
M - Feb 25 |
16 | Regulatory Strategies: Reversible Covalent Modification |
10, pp. 283-288
| Dr. Ziegler |
W - Feb 27 |
17 | Regulatory Strategies: Regulatory Proteins, Proteolytic Cleavage |
14, pp. 389-391; 10, pp. 288-299 | Dr. Ziegler |
F - Feb 29 |
18 | Membranes: Lipids; Quiz 2 |
12, pp. 326-335
| Dr. Ziegler |
M - Mar 3 |
19 | Membranes: Proteins |
12, pp. 336-348
| Dr. Ziegler |
W - Mar 5 |
20 | Membranes: Transport 1 | 13, pp. 351-376
| Dr. Ziegler |
Th - Mar 6 |
Review/Help Session, 4:00-5:00, Chavez 111 |
| Dr. Ziegler |
|
F - Mar 7 |
21 | Membranes: Transport 2 |
13, pp. 351-376
| Dr. Ziegler |
M - Mar 10 |
EXAM 2 |
|
Dr. Ziegler |
|
W - Mar 12 |
22 | Signal Transduction Pathways 1 |
14, pp. 381-403 |
Dr. David Gang |
F - Mar 14 |
23 | Signal Transduction Pathways 2 |
(same as Lec 22) |
Dr. David Gang |
Mar 15-23 |
Spring Break |
|||
M - Mar 24 |
24 | Metabolism and Bioenergetics |
15, pp. 409-430 (review 11-14 & pp. 208-211) |
Dr. Miesfeld |
W - Mar 26 |
25 | Glycolysis 1: Glycolytic Pathway |
11, pp. 303-308; 16, pp. 433-452 |
Dr. Miesfeld |
F - Mar 28 |
26 | Glycolysis 2: Regulation of Glycolysis, Fate of Glycolytic Intermediates and Products |
16, pp. 452-471 |
Dr. Miesfeld |
M - Mar 31 |
27 | Redox Reactions, Enzyme Cofactors and Pyruvate Dehydrogenase |
15, pp. 420-430; 17, pp. 477-481; 18, pp. 506-509 |
Dr. Miesfeld |
W - Apr 2 |
28 | Citrate Cycle |
17, pp. 475-498 |
Dr. Miesfeld |
F - Apr 4 |
29 | Electron Transport System; Quiz 3 |
18, pp. 502-520 |
Dr. Miesfeld |
M - Apr 7 |
30 | Oxidative Phosphorylation |
18, pp. 520-537 |
Dr. Miesfeld |
W - Apr 9 |
31 | Photosynthetic Light Reactions and Photosynthetic Phosphorylation |
19, pp. 541-562 |
Dr. Miesfeld |
| Th - Apr 10 | Review/Help Session, 4:00-5:00, Chavez 111 |
| Dr. Miesfeld |
|
| F - Apr 11 |
32 | Photosynthesis: Calvin Cycle, C4 and CAM |
20, pp. 565-577 |
Dr. Miesfeld |
M - Apr 14 |
EXAM 3 |
Dr. Miesfeld |
||
W - Apr 16 |
33 | Carbohydrates 1: Pentose Phosphate Pathway and Gluconeogenesis | 20, pp. 577-589 |
Dr. Miesfeld |
F - Apr 18 |
34 | Carbohydrates 2: Glycogen Metabolism |
21, pp. 592-614 |
Dr. Miesfeld |
M - Apr 21 |
35 | Lipid Metabolism 1 |
22, pp. 617-634 |
Dr. Miesfeld |
W - Apr 23 |
36 | Lipid Metabolism 2 |
22, pp. 634-646 |
Dr. Miesfeld |
F - Apr 25 |
37 | Lipid Metabolism 3 |
26, pp. 739-756 |
Dr. Miesfeld |
M - Apr 28 |
38 | Amino Acid Metabolism 1; Quiz 4 |
23, pp. 649-676 |
Dr. Miesfeld |
W - Apr 30 |
39 | Amino Acid Metabolism 2 |
24, pp. 679-706 |
Dr. Miesfeld |
F - May 2 |
40 | Metabolic Integration 1 |
27, pp. 760-781 |
Dr. Miesfeld |
M - May 5 |
41 | Metabolic Integration 2 |
(same as Lec 40) |
Dr. Miesfeld |
M - May 5 |
Review/Help Session, 4:00-5:00, in reg. classroom (ILC 120) |
Dr. Miesfeld |
||
W - May 7 |
EXAM 4 (3:00-3:50 pm, ILC 120) |
Dr. Miesfeld |
