Office Hours:

Dr. Miriam Ziegler (Instructor, Co-Course Coordinator) office hours: daily May 19-June 5, 10:00-11:00 a.m. in the classroom (or by appointment in Bio W 345); 626-9388 zieglerm@u.arizona.edu	Dr. Marc Tischler (Instructor, Co-Course Coordinator) office hours: daily June 13-July 9, 10:00-11:00 a.m. in the classroom (or by appointment in BioW 358); 626-6130 tischler@email.arizona.edu
Dr. James Hazzard (Instructor) office hours: daily May 19-June 12, 10:00-11:00 a.m. in the classroom (or by appointment in BioW 342A); 621-7118 jhazzard@email.arizona.edu

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There will be a special freshman chemistry review session covering concepts of chemical equilibrium, pH, pK_a, buffers, etc. outside of class during the first week of classes. To make it possible for as many students as possible to attend, the SAME REVIEW will be given TWO DIFFERENT TIMES during the first week of classes during the office hour immediately after class:
Monday May 19 (10:00-11:00 am, CHEM 111 (the classroom, right after regular class), and
Tuesday May 20 (10:00-11:00 am, CHEM 111 (the classroom, right after regular class).
Don't come twice! Attendance at this review is not "required", since it covers material you learned in general chemistry, but note that understanding of what is covered in the review IS required in this course, and the review may be the most painless mechanism for being sure you know the material and can work with it, rather than trying to review it entirely on your own. We take the time to help you with this because experience suggests that without substantial review many students do not remember this elementary chemistry material well enough to work with it as they must in biochemistry. It will be expected starting on Wednesday 5/21 in class that students will be thoroughly familiar with this review material, since it is fundamental in biochemistry. The contents of the review are mainly included in this PDF, which is also linked on the lecture notes page: gen chem review. It is also expected that you will remember (from junior high or high school algebra) how to use logarithms (base 10 and base e). Those concepts will not be reviewed in this course, but there's a bare-bones reminder review posted at logarithms review, also linked on lecture notes page.

Examinations: Three one-hour examinations (100 points each) will be given as indicated on the schedule, at 9:00 a.m. Wed. June 4, Mon. June 23, and Thurs. July 10. The last hour examination will be at the scheduled time for the final exam (9:00 a.m. Thurs., July 10, 2008). All 3 hour exam count toward the final grade -- no major exam is dropped. In addition to the hour exams, there will be three 10-min quizzes (20 points each) during class as indicated on the schedule. The exam and quiz format will be based on short answers and fill-in-the-blank type questions, with some calculations and perhaps multiple choice questions on quizzes. Several old hour exams are posted on the "Study Guides" page. Each 10-minute quiz may cover material to be discussed on the day of the quiz, i.e., preparation for class, as well as questions from earlier lectures. One quiz will be dropped, either one missed quiz or the lowest quiz score. There will be no make-up quizzes, and no excused absences from the 10-min quizzes need to be documented by you unless you miss more than one quiz, both absences being for excused reasons. In this unusual circumstance, you should bring the documentation for both missed quizzes to Dr. Ziegler or Dr. Tischler within 1 week after the second (excused) missed quiz.
Exam review/help sessions will be held during instructors' office hours immediately after class in the regular classroom, CHEM 111:
--Tues., June 3, 10:00 a.m. (right after class), Chem 111 (Dr. Ziegler)
--Fri., June 20, 10:00 a.m. (right after class), Chem 111 (Dr. Hazzard and Dr. Tischler)
--Wed., July 9, 10:00 a.m. (right after class), Chem 111 (Dr. Tischler)

The hour examinations must be taken at scheduled times. If possible, an examination may be rescheduled for medical reasons, or death in the family, but only if the emergency is documented by an appropriate letter. If a medical emergency does arise, it is the student's responsibility to contact Dr. Ziegler (Exam 1), or Dr. Tischler (Exams 2 and 3) by telephone or email prior to the start of the examination to reschedule the exam for the next day. (The only exception would be for a student who also has an excused absence for the day after the exam, but again, that requires discussion with Dr. Ziegler or Dr. Tischler.) The telephone is by far the most effective means of arranging a time to reschedule an exam, so if you have to leave a voicemail message or send an email, be sure to leave a telephone number where you can be reached.

IMPORTANT NOTE ABOUT CALCULATORS: The course requires a non-programmable scientific calculator that can do logs and natural logs (ln) for exams and for some quizzes. Such calculators can be bought at discount stores for less than $10; no sharing of calculators will be permitted during exams and quizzes. Be sure you understand how to use the calculator (logs and antilogs) before you bring it to an exam. No programmable calculators, and no sharing of calculators, will be permitted during exams and quizzes, so please don't even ask!

Regrading of Exams: Requests for regrading of exam answers must be made in writing on your own separate piece of paper attached to the exam and turned in to the instructor in charge of that exam within five class periods (one week) after the return of exams. DO NOT WRITE ON THE EXAM ITSELF. In your request, you should explain why your answer is correct. The entire exam may be regraded when any regrading is requested.

Cheating: Cheating will absolutely not be tolerated. The Student Code of Conduct may be found at http://w3.arizona.edu/~studpubs/policies/studcofc.htm. Anyone caught cheating will fail this course and be subject to disciplinary proceedings as prescribed by university policies, described at http://w3.arizona.edu/~studpubs/policies/studdisc.htm. Potential outcomes from this include expulsion from the University. Changing your answer on a test after it has been returned, and requesting a regrading of the exam, is cheating. We will routinely photocopy 15-25% of the exams to discourage this form of cheating, so don't do it!

Final grades in the course:
All grades will be recorded on the course D2L site:
http://www.d2l.arizona.edu
Access the summer BIOC 460 D2L site by web auth log-in. The final grade will be determined based on the total points out of 340 points: 300 pts from 3 hour exams and 40 pts from the best 2 out of 3 10-min quizzes. Course grades on a total point basis out of 340 points will be curved if necessary based on overall class performance, but the final course grade cut-offs (minimum percentage grades required) for final grades of A, B, C, and D, respectively, will be no higher than 90, 80, 70, 60%. Although an approximate letter grade distribution will be posted for each exam (go to "Gradebook" link above), those posted letter grade distributions for individual exams will be intended simply as general guidelines for students to assess their ongoing performance in the class; we will not record letter grades for individual exams and thus will not agonize over the posted "cut-offs" for each exam. Students are responsible for checking their grades on the course D2L site to confirm that their recorded exam and quiz scores are correct. Keep your copy of each original graded exam and quiz until the end of the semester to document any discrepancies.

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Lecture Schedule - Summer 2008 (tentative)
Lecture notes (password-protected) will be posted in general by the end of the day before the lecture.
**** username: bioc460
**** password: protein
NOTE: Lecture schedule is tentative; revisions will be posted as needed. Check announcements at "What's New".
Print out PDFs of required background (review) on logarithms and on concepts of general chemistry, which includes sample problems and answers, to be sure you are able to work with those concepts. See homepage or "What's New" for times and locations of 1st week general chem review.

Date	Lecture	Topic	6th ed. Chapters, pp.	Instructor
M - May 19	1	Introduction, Properties of Water	1	Ziegler
T - May 20	2	Bioenergetics, Amino Acids	pp. 11-14 & 208-210; 2, pp. 25-34	Ziegler
W - May 21	3	Amino Acids, Peptides	2, pp. 34-37	Ziegler
R - May 22	4	Peptides, Protein Secondary Structure	2, pp. 37-45	Ziegler
F - May 23	5	Proteins, Tertiary & Quaternary Structure	2, pp. 45-53	Ziegler
M - May 26		Memorial Day (HOLIDAY)
T - May 27	6	Proteins: Folding	2, pp. 53-62	Ziegler
W - May 28	7	Protein Function: Ligand Binding (Myoglobin, Hemoglobin); Quiz 1	7, pp. 183-199	Ziegler
R - May 29	8	Enzymes: Introduction, Kinetics	8, pp. 205-225	Ziegler
F - May 30	9	Enzymes: Kinetics, Inhibition	8, pp. 225-236	Ziegler
M - June 2	10	Enzymes: Inhibition, Catalytic Strategies	9, pp. 241-254	Ziegler
T - June 3	11	Enzymes: Catalytic Strategies; help session after class	9, pp. 241-254	Ziegler
W - June 4		EXAM 1
R - June 5	12	Regulatory Strategies: Allosteric Regulation, Isozymes, Covalent Modification	10, pp. 275-288	Hazzard
F - June 6	13	Regulatory Strategies: Regulatory Proteins, Proteolytic Cleavage	10, 288-299; 14, pp. 389-391	Hazzard
M - June 9	14	Membranes: Lipids	12, pp. 326-335	Hazzard
T - June 10	15	Membranes: Proteins	12, pp. 336-348	Hazzard
W - June 11	16	Membranes: Transport 1	13, pp. 351-376	Hazzard
R - June 12	17	Membranes: Transport 2 or catch-up; Quiz 2	13; pp. 351-376	Hazzard
F - June 13	18	Metabolic Concepts	14	Tischler
M - June 16	19	G-Protein Signaling	15	Tischler
T - June 17	20	Insulin Signaling	15	Tischler
W - June 18	21	Glycolysis/Gluconeogenesis 1	16	Tischler
R - June 19	22	Glycolysis/Gluconeogenesis 2	16	Tischler
F - June 20	23	PDH and Citrate Cycle (on Exam 3); help session after class	17	Tischler, Hazzard
M - June 23		EXAM 2
T - June 24	24	Redox; Respiratory Chain	18	Tischler
W - June 25	25	Oxidative Phosphorylation	18	Tischler
R - June 26	26	Pentose Pathway and Antioxidants	20	Tischler
F - June 27	27	Glycogen - Allosteric Control	21	Tischler
M - June 30	28	Glycogen - Hormonal Control	21	Tischler
T - July 1	29	Cholesterol; Quiz 3	26	Tischler
W - July 2	30	Lipid Transport	26	Tischler
R - July 3	31	Lipolysis; β-Oxidation; Lipogenesis	22	Tischler
F - July 4		Independence Day (HOLIDAY)
M - July 7	32	Lipid Regulation	22, 26	Tischler
T - July 8	33	Ammonia Metabolism; Urea Cycle	23	Tischler
W - July 9	34	Nitrogen Metabolism; help session after class	24	Tischler
R - July 10		EXAM 3