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Course Information | 462a Home
Course Objectives
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Biochemistry is the science dealing with how biological processes occur at the molecular level, and our primary goal is to begin understanding those processes, using your strong backgrounds in chemistry, biology, and mathematics to do so. We will study the structure and function of the molecules of living cells, with a particular emphasis on proteins. BIOC 462a provides the intellectual framework you will need to approach the concepts covered in the other two courses in the biochemistry core sequence, BIOC
462b and a semester of molecular biology/nucleic acids biochemistry (BIOC 466). A second goal is to become adept at reading and understanding biochemical literature, and reading, understanding, and solving biochemical problems; this goal is addressed particularly in discussion sections and problem sets.
The lab course, BIOC 463a, provides a thorough treatment of many of the experimental tools used by biochemists to gain these insights.
Note that this is a majors course; it is assumed that you have the necessary math and science background to be taking this course, a lot of study time outside class will be necessary
(at least 3 hours outside class for each of the four hours a week in class), and performance expectations will be high. Our hope is that by the end of the 3-semester BIOC 462a,b-BIOC 466 sequence you will have developed not only an understanding and a real appreciation of the molecular bases for life processes, but also new knowledge and tools to apply in your intellectual approaches to other courses and to your professions.
Instructional Staff
Undergraduate Preceptors
(See "Where to get help" at end of syllabus, and PDF table of all hours of assistance.)
Expected Student
Background
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Biochemistry 462a is the first of three courses that provide an in-depth introduction to biochemistry and molecular biology; the other two courses
are BIOC 462b and BIOC 466. Students are required to have completed the equivalent of: BIOC 181, two semesters of organic chemistry, and at least one semester of calculus when beginning this series.
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Biochemistry 460 is an alternative course available
for students who are not biochemistry majors and are interested
in a one-semester, 3 unit introductory course covering BIOC 462a
and 462b topics. A companion 2 unit course, BIOC 461, covers much
of the material (nucleic acids and molecular biology) taught in
BIOC 466 (or MCB 411). Note that BIOC 462a,b is a 2-semester sequence; BIOC
462a is not a "stand-alone" course, so if you plan to take only
one biochemistry course, it should be BIOC 460, which will provide
you with a more complete introduction (including metabolism and signaling) than BIOC 462a alone.
Text
- Nelson & Cox, Lehninger Principles of Biochemistry,
5th edition, 2008 -
Required
Textbook website: http://bcs.whfreeman.com/lehninger/
. A copy of the text is available on reserve in the Science and Engineering Library.
- (A paperback "Study Guide and Solutions Manual" by Osgood and Ocorr to accompany the textbook is NOT required or even recommended for purchase, but a copy is available on reserve in the Science and Engineering Library if you want to consult detailed solutions to end-of-chapter problems from the textbook. These solutions are at the end of the Study Guide book.)
- NOTE: A simple calculator that can do logs and natural logs (ln) will
be required for many problem sets and exams.
Lecture Notes
- Students will be expected to take notes in class. Bare-bones outline class notes, usually in powerpoint with figures to be discussed will be posted in PDF format on the course web page under "lecture notes" and are intended for viewing with Internet Explorer 5.1 or Safari or Firefox as a browser, though other browsers should work. Username and password are required. Notes may be revised up until 5 pm the day before the lecture.
NOTE: most of the molecular graphics links have been converted into a program called Jmol, which works on most browsers, but not on Internet Explorer on a Mac in OS X; you can have more than one browser installed on your computer, and can have more than one browser running at the same time. The Molecular Graphics link on website has more info. A directory of most of the molecular structures available on this course website is at http://www.biochem.arizona.edu/classes/bioc463a/jmol/routines/routines.html.
Lectures
Discussion Sections
- Honors Section
- The 462a honors section, BIOC 462a-007H (5 units), has 2 discussion sections each week: 12 noon on Wed. (FCS 223) and 12 noon on Fri. (BioW 243). Dr. Chad Park will be in charge of the honors section discussions and projects. The honors section will have its own website for honors-specific information and announcements, at http://www.biochem.arizona.edu/classes/bioc462/462a/462aH-ann.htm.
- Non-Honors Sections
- The other six discussion sections are scheduled for Thursdays. Every student should
be registered for one section and must attend that section
except under unusual circumstances. Problem sets are collected,
graded, recorded, and handed back to students by section.
Discussion Section |
Time and Location |
Instructors |
1 |
8:00-8:50 Th, BioW 219 |
TA: Dylan; preceptor: Yomi |
2 |
8:00-8:50 Th, Bio W 210 |
TA: Telsa; preceptor: Aarthi |
3 |
2:00-2:50 Th, S Sci 411 |
TA: Reid; preceptor: Jimmy |
4 |
2:00-2:50 Th, S Sci 206 |
TA: Dylan; preceptor: Megan |
5 |
3:00-3:50 Th, BioE 314 |
TA: Reid; preceptor: Jimmy |
6 |
3:00-3:50 Th, PAS 414 |
TA: Telsa; preceptor: Hayley |
7 (honors) |
12:00-12:50 Wed, BIO W 212
12:00-12:50 Fri, BIO W 243 |
Dr. Park; preceptor: Trahern |
- Most Wed./Thurs. discussion section meetings will have two "parts": 1)
working in small groups for final polishing of solutions to the problem set for that week, which will be due the next day, and 2) new material, interpretation or calculations involving data from the original literature, which will be handed out to the small groups at the discussion section but will not be posted online; exams may include questions based on the latter problems as well as on posted problem set material.
General Policies and Grading
- Exams. There will be 3 100-point hour exams and a 200-point final exam (the Wed. of finals, 12/17/2008, 2:00-4:00 pm). BE SURE YOU NOTE THE EXAM DATES,
WHICH ARE ON THE LECTURE SCHEDULE. The final exam is a 2-hour exam
covering both the last part of the course (about 40-50% of final exam)
and questions from the first three parts of the course (about 50-60% of
the exam). All 4 exams "count" -- no exam grade will be dropped. Students are expected to take all exams at their scheduled
times. Students will only be excused from taking an exam at the scheduled
time for illness or a death in the family or other university-excused absence, and then ONLY IF DR. MCEVOY
RECEIVES NOTIFICATION BEFORE 3:00 P.M. THE DAY OF THE EXAM.
That notification can be in the form of a telephone call to her office
phone (number above; voicemail message is acceptable -- time of message
is recorded), an email (address above), or a fax to the departmental
office fax: 520-626-9204 with Dr. McEvoy's name on it. Be
sure to provide contact information for setting up a time for a make-up
exam, preferably both an email address and a telephone number
where you can be reached. Written proof of the problem, such as a note from a physician,
is required in order to take a make-up exam, which should be taken as
soon as possible, normally the next day. If the student has a medical
excuse covering more than one day, the make-up should be taken on the
first day after the medical problem is resolved; in any case, all make-up
exams must be completed before the graded original exams are handed
back in class, which will generally be a week after the original exam
date. Answer keys for exams will usually be posted on the website at
the end of the day that the exams are returned to students.
You'll need a simple calculator that can do logs and
natural logs (ln) for exams, and it is expected that you will be able to do simple integral logs10 and antilogs without a calculator.
- Short quizzes. Each
of the 4 short quizzes (all multiple choice or very short answer questions,
dates in lecture schedule) is worth 20 points; the lowest quiz grade
will be dropped, and no excuse is needed for missing one quiz for any
reason, but the missed quiz would become the dropped grade. There
will be no make-up quizzes, so if you skip one quiz and then
are ill for another, you'll already have used up your "freebie", and one of the missed quizzes will be counted as a zero. If you miss a quiz for an excused reason, SAVE your documentation in case you have another excused absence, in which case documentation for both would be required for normalizaton of total quiz grades. The quizzes individually don't count for a lot of points, but those 60 possible points
could easily make a letter grade difference at the end of the course.
Answer keys for quizzes will be posted on the website, usually the day
after the quiz.
- Problem Sets. Each
problem set is worth 15 points. There will be twelve assignments, all due on Fridays at the beginning of class except P.S. 5 and P.S. 6 -- see lecture schedule. The
lowest problem set grade will be dropped, so the maximum problem set
point total is 165. Problem sets will normally not be regraded except in cases
of arithmetic errors in the total. Answer keys for problem sets will
generally be posted on the website at the end of the day that the assignments
were due, but on rare occasions posting of key will be delayed by as much as 3 days. Please
also see notes below on the subject of problem sets.
- Grading. The final
grade will be determined based on the total points in the class (sections 1-6 out
of 725 points: 300 pts from hour exams,
200 pts from final exam, 60 pts from 3 best quizzes, 165 pts from 11 best problem sets; section 7H out of 900 points, the 725 points described above plus 175 points for the honors discussions/projects). Grades will
be curved if necessary based on class performance, but the final course
grade cut-offs (minimum percentage grades required) for final grades
of A, B, C, and D, will be no higher than 90, 80, 70,
and 60% respectively. Although a letter grade distribution will be posted for each exam,
those posted letter grade distributions for individual exams will be
intended simply as general guidelines for students to assess their ongoing
performance in the class; we will not record letter grades for individual
exams and thus will not agonize over the posted "cut-offs" for each
exam.
- Regrading of Exams.
Do NOT write anything on the exam itself if you want to turn it in for regrading. Requests for regrading of exam questions must be made in writing
and turned in to Dr. McEvoy within one week after the return of
exams; later requests for regrading will not be accepted. In your
request, you should explain why your answer is correct. Dr. McEvoy
will generally refer the question to the member of the instructional
staff who graded the relevant question(s) to ensure fairness and consistency,
and she will review the decisions. Be aware that the entire test may
be regraded when a regrading request is made.
- Cheating. Cheating
will absolutely not be tolerated. The Student Code of Conduct may
be found at http://w3.arizona.edu/~studpubs/policies/studcofc.htm.
Anyone caught cheating will fail this course and be subject to disciplinary
proceedings as prescribed by university policies, described at http://w3.arizona.edu/~studpubs/policies/studdisc.htm.
Potential outcomes of disciplinary proceedings include expulsion from
the University. Changing your answer on a test after it has been returned
and then requesting a regrading of the exam is cheating. We will copy
random exams to discourage this form of cheating, so don't do it! While
we enthusiastically encourage group efforts in discussing and solving
problem set problems, the work you hand in for problem sets must
be your own calculations and written in your own words. Stealing problem sets or copying problem set answers would definitely also be a form of academic dishonesty. We
obviously don't want or expect to have to deal with cheating, and you
certainly won't want to deal with the consequences! Bottom
line: Don't do it!
- Checking your recorded grades.
It is strongly advised that students
retain all graded written work in the course at least until they have
checked the posted grades on the web to be sure they have been accurately
recorded. A human being enters the grades into the computer,
and errors sometimes occur despite our best efforts; you should check
your own recorded grades carefully as soon as they're posted. (See "Grades"
on the D2L website for this course.)
Course
Format
- Classes: Each week lecture will be held in CHEM 111
on Monday, Wednesday and Friday at 3 PM. In addition to the 3 lectures/week, there are small discussion
sections that meet on Wednesdays and Fridays (section 7H) or Thursdays (sections 1-6) at the times scheduled. You should
be enrolled in one section and that is the section you should attend;
your problem sets will be handed in for grading by the TA for that section,
and returned in that discussion section by the TA the next week. Problem sets are due at beginning of class Fridays (except Problem Sets 1 and 7, due the next Monday).
- Discussion sections/problem sets: Problem
set assignments will be posted on the web.
Each assignment will consist of questions/problems that will be discussed
in the discussion section the following Thursday. During the discussion
section, the students will be divided into small groups. You will work
with your group to answer the questions, with help as needed from the
instructor and the TA. Our aim is to help you work through the problems
to the correct conclusion, but not to tell you the answers. We
expect that every student will arrive at discussion section every week
with essentially all the work on the problem set already done,
and armed with questions for other students and instructors about what
he/she could not complete independently. Each student will write out the answers to all questions and turn them
in at the beginning of lecture on the indicated due date in
envelopes or folders
labeled with your
TA and/or section number. Be sure to put your section
number and TA name, as well as your own name, on the assignment. While
students are definitely encouraged to work together on solutions to
the assigned questions, it is expected that each student will write
out the answers independently to hand in; direct copying of assignments
will be regarded as cheating. You must show your work/reasoning on
all mathematical problems. NOTE: Late problem sets are not
accepted. A problem set is considered late if it is not
turned in by 3:10 p.m. on the date it is due (generally a Friday).
An envelope or folder for each TA will be provided in class for turning in problem sets,
but those envelopes will be picked up at 3:10 p.m. If you hand in your assignment
to a TA during class but after 3:10 p.m., 3 points will be immediately
deducted; assignments handed in anytime after class, including as the
TA walks out the door of the classroom, will receive no credit. If
you can't come to class that day, it is your responsibility to get your
problem set to the course staff before 3:10 p.m. -- you can hand
it in early to an instructor or TA, email it to your TA, leave it in
the Biochemistry & Molecular Biophysics Dept. office (362 Biol.
Sciences West) to the attention of Dr. McEvoy with section number,
TA NAME, and time noted, or fax it to the departmental
office to the attention of Dr. McEvoy (fax number 520-626-9204). If
you fax a problem set, include a cover sheet with how to reach you
if there's a problem with it, and be sure to include Dr. McEvoy's
name, course number, section number and TA NAME. NOTE
THAT FAXES OF DOCUMENTS WRITTEN IN PENCIL ARE GENERALLY ILLEGIBLE! Finally, if there's a real emergency, e.g., if you’re in a car accident in Phoenix at noon on the due day, call Dr. McEvoy to see if something can be worked out.
The last approximately 20-25 minutes of each Thursday discussion section will be spent on discussion of new material (problems/data interpretation), usually from original literature, and NOT posted online at all. It is anticipated that some of this material from discussions, like some of the problem set problems, could provide the basis for exam questions.
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Honors Section Discussion sections/problem sets: Like sections 1-6, the honors section will be responsible for turning in the problem sets posted on the web each Friday, and will hand in the solutions when they are due for the rest of the class (usually the following Friday). There may be different or additional problems for the honors section, at the discretion of Dr. Park, who will also be in charge of the Wednesday and Friday meetings of the honors section and special project(s) or papers required of the honors section.
Course
Website: http://www.biochem.arizona.edu/classes/bioc462/462a/462a.html
- Course announcements, lecture notes, problem set assignments, problem set and exam answer keys, exam grade distributions, and instructions for graphics viewing will be available on the web. (Actual grade posting will be on D2L.) The course website should be fine for viewing with Safari, Mozilla Firefox, or current versions of Netscape, or with Internet Explorer 5.1 or later (except that the molecular graphics in Jmol don’t work with Explorer on a Mac with OS X). For PRINTING, use the PDF versions of notes and problem sets. (You can download browsers free from the web.)
Where to Get Help [PDF of all staff office hours/availability]
- Each member of the course staff has a scheduled office hour each week, or if necessary will see you at other times by appointment, in addition to being available during the discussion sections. After coming to class and consulting the notes
and the textbook for answers, you are strongly urged to take the initiative
to get help from the course staff or preceptors with anything you do not understand. We also encourage the use of email to ask questions. On the other hand, sometimes questions are much more efficiently
addressed either face-to-face or over the telephone, where some "back
and forth" clarification is possible.
- Undergraduate Preceptors
In addition, we have six "alumni" of the BIOC 462A course who will be on-call to answer any of your biochemistry questions. These Undergraduate Preceptors are each available for 3 hours every week. To schedule an appointment with any of the preceptors, simply find one on the contact list below who would be available during a time that is convenient for you (see complete schedule on course website under Course Info) and e-mail that preceptor no less than 24 hours in advance. The preceptor will respond to your e-mail to arrange a place to meet. In the past, informal "study groups" made up of students who got together regularly with preceptors have been very beneficial for student learning. With the assistance of our preceptors, we are confident that there will be plenty of staff available to help you throughout the course.
Course
Information
| 462a
Home
Biochemistry 462a
http://www.biochem.arizona.edu/classes/bioc462/462a/462a.html
Department of Biochemistry and Molecular Biophysics
The University of Arizona
mcevoy@email.arizona.edu
All contents copyright © 1998-2008. All rights reserved.
Last revised fall 2008
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