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462a
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A major contribution to the Bohr effect involves the
C-terminal His of each b subunit.
In the deoxy state, this His forms a salt bridge to Asp 94,
if the His ring is protonated. The salt bridge stabilizes
the protonated form of the His, causing a high pKa, in the
deoxy state. The salt bridge does not form in the oxy state.
Thus protonation of His-146 favors the deoxy
conformation.
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462a
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Biochemistry 462a
http://www.biochem.arizona.edu/classes/bioc462/462a/462a.html
Department of
Biochemistry and Molecular
Biophysics
The University of Arizona
mawells@email.arizona.edu
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