Introduction - This script shows the conformational change, "induced
fit", that results from glucose binding to hexokinase.
Scroll down until the text corresponding to the view is visible. (Based
on 2yhx.pdb, C.M.Anderson et al. J. Mol. Biol. 123
15 (1978) and 1hkg.pdb, W.S.Bennett & T.A.Steitz Philos.
Trans.R.Soc.London 293 43 (1981)).
This is hexokinase (HK) without its substrate, glucose shown as a
ribbon diagram.
This is a cartoon of HK with GLUCOSE
bound in the active site
This is HK shown in a spacefilling model. Notice the open cleft. .
And as a spacefilling model. Notice how the cleft closed when the
enzyme bound glucose.