References
  • Altamirano MM, Blackburn JM, Aguayo C, and Fersht A. "Directed evolution of new catalytic activity using the a/b-barrel." Nature 403, 10 February 2000.
  • Arnold HF."Directed Enzyme Evolution" http://www.che.caltech.edu/groups/fha/Enzyme/directed.html
  • Branden, C. and Tooze, J. Introduction to Protein Structure, Second Edition. New York: Garland Publishing, 1999.
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE. "The Protein Data Bank." Nucleic Acids Research, 28. 235-42. http://www.rcsb.org/pdb/index.html.
  • Birkbeck College. "Overview of enzymes." 1996. http://www.cryst.bbk.ac.uk/PPS2/course/section12/enz_over.html
  • Crameri A, Raillard S-A, Bermudez E, and Stemmer WPC. "DNA shuffling of a family of genes from diverse species accelerates directed evolution." Nature 391, 15 January 1998.
  • Garrett RH and Grisham CM. Biochemistry, Second Edition. Fort Worth: Saunders College Publishing/Harcourt Brace College Publishers, 1999.
  • Harayama S. "Artificial evolution by DNA shuffling." Trends Biotechnology, February 1998; 16(2): 76-82.
  • Hegyi H and Gerstein M. "The relationship between protein structure and function, with application to the yeast genome." 1998. http://bioinfo.csb.yale.edu/genome/foldfunc/Fig1-struct.html
  • Klug, William S., and Cummings, Michael R. Concepts of Genetics, Sixth Edition. Upper Saddle River, New Jersey: Prentice Hall, Inc, 2000.
  • Thermogen. "Addressing the challenges of biocatalysis." http://www.thermogen.com/tech.html.

Origin of Structures:

  • "Complex of Indole-3-Glycerophosphate Synthase from Sulfolobus solfataricus with Indole-3-Glycerolphosphate at 2.0 Å Resolution." Hennig M, Darimont B, Kirschner K, Jansonius JN. 19 February 1998. PDB #1A53.
  • "Indole-3-Glycerolphosphate Synthase from Sulfolobus solfataricus at a 2.0 Å Resolution." Hennig M, Darimont B, Kirschner K, Jansonius JN. 11 August 1995. Medline. PDB #1IGS.
  • "Crystal structure of Phosphoribosyl Anthranilate Isomerase from Thermotoga maritima at 2.0 Å resolution. " Hennig M and Jansonius JN.13 September 1996. Medline. PDB #1NSJ.
  • "Leishmania mexicana Triose Phosphate Isomerase." Williams JC and Weirenga RK.17 June 1997. PDB #1AMK.
Implications
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Nikki Jarrett, 11/20/00
Biochemistry 462bH, Dr. D. Bourque