Nicotine Metabolism and Carcinogenesis

A Metabolic Investigation


The recently elucidated 2'-hydroxylation pathway of nicotine--an addictive drug found in tobacco products--adds further evidence that cigarettes can be detrimental to human health. Although nicotine itself does not cause cancer, the products of nicotine metabolism are highly carcinogenic, especially to lung tissue. The following investigation highlights nicotine metabolism, explaining the biochemical pathways and examining the implications upon human health, science, and society as a whole.


Smoking, Nicotine, and Cancer

Nicotine Metabolism & Experimental Procedures

NNK Metabolism and Carcinogenesis  

Detoxification of Nicotine Metabolites

Future Implications of the 2'-hydroxylation Pathway

Works Cited


by Anna R. Bieging

e-mail: abieging@u.arizona.edu

The University of Arizona -- Biochemistry 462b Honors Web Document Project

Dr. Don P. Bourque, instructor, Spring 2001

Last Revised May 8th, 2001