A special thanks to Dr. Ambudkar, Dr. Pallis, Dr. Wunderli-Allenspach, Dr. Altenberg, and Dr. Ferte for permission to use figures from their publications on this webpage. Permission from the respective journals in question was also obtained.

1. Ambudkar, SV, Dey, S, Hrycyna, CA, Ramachandra, M, Pastan, I and MM Gottesman. Biochemical, Cellular, and Pharmacological Aspects of the Multidrug Transporter. Annual Reviews in Pharmacology Toxicology 39: 368-391, 1999.

2. Castro, AF, Horton, JK, Vanoye, CG, and GA Altenberg. Mechanism of Inhibition of P-glycoprotein-Mediated Drug Transport by Protein Kinase C Blockers. Biochemical Pharmacology 58: 1723-1733, 1999.

3. Dey, S, Ramachandra, M, Pastan, I, Gottesman, MM, and SV Ambudkar. Evidence for two nonidentical drug interaction sites in the human P-gpycoprotein. Proceedings of the National Academy of Sciences 94: 10594-10599, 1997.

4. Ferte, J. Analysis of the tangled relationships between P-glycoproteins-mediated multidrug resistance and the lipid phase of the cell membrane. European Journal of Biochemistry 267: 277-294, 2000.

5. Hammerle, SP, Rothen-Rutishauser, B, Kramer, SD, Gunthert, M, and H Wunderli-Allenspach. P-glycoprotein in cell cultures: a combined approach to study expression, localization, and functionality in the confocal microscope. European Journal of Pharmeceutical Sciences 12: 69-77, 2000.

6. Idriss, HT, Hannun, YA, Boulpaep, E, and S Basavappa. Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say! Journal of Physiology 524(3): 629-636, 2000.

7. Kerr, KM, Sauna, ZE, and SV Ambudkar. Correlation between steady-state ATP hydrolysis and Vanadate-induced ADP trapping in human P-glycoprotein: evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates. Journal of Biological Chemistry 276: 8657-8664, 2001.

8. Loo, TW, and DM Clarke. Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques. Biochimica et Biophysica Acta 1461: 315-325, 1999.

9. Pallis, A and N Russell. P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a shingomyelin-ceramide apoptotic pathway. Blood 95 (9):2987-2904, 2000.

10. Sauna, ZE, and SV Ambudkar. Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein: the two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes. Journal of Biological Chemistry 276: 11653-11661, 2001.

11. Seelig, A and Ewa Landwotjtowicz. Structure-activity relationship of P-glycoprotein substrates and modifiers. European Journal of Pharmeceutical Sciences 12: 31-40, 2000.