 Figure 13: Malonyl CoA inhibits the entry of fatty acids into the mitochondria, and thus inhibits fatty acid oxidation. |
Fatty Acids are carried to the tissues by lipoproteins. There, they are activated and transported into the inner mitochondrial membrane to undergo beta-oxidation. The proteins that allow transport of fatty acids into the membrane are carnitine acyltransferases. Malonyl CoA, a component of lipid biosynthesis, as well as an integral part of the new pathway, is a potent inhibitor of carnitine acyltransferase I. |
Department of Biochemistry and Molecular
Biophysics
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