References

[Intro] [ C75 and Fatty Acid Metabolism] [AMPK and Neuropeptides] [C75 and Neuropeptides] [Discussion] [References]

Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, Thupari JN, Connolly EC, Huganir RL, Richardson C, Witters LA, Kuhajda FP, Ronnett GV., C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. J Biol Chem. 2004 Jan 30;279(5):3817-27. Epub 2003 Nov 13.

Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ., AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem. 2004 Mar 26;279(13):12005-8. Epub 2004 Jan 23.

Cha SH, Hu Z, Lane MD., Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3. Biochem Biophys Res Commun. 2004 Apr 30;317(2):301-8.

Neary NM, Goldstone AP, Bloom SR., Appetite regulation: from the gut to the hypothalamus. Clin Endocrinol (Oxf). 2004 Feb;60(2):153-60. Review. No abstract available.

Winder, WW and Hardie, DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999 Jul;277(1 Pt 1):E1-10.

Thupari JN, Kim EK, Moran TH, Ronnett GV, Kuhajda FP. Chronic C75 Treatment of Diet-Induced Obese Mice Increases Fat Oxidation and Reduces Food Intake to Reduce Adipose Mass. Am J Physiol Endocrinol Metab. 2004 Jan 21

Other Sources

The RCSB Protein Data Bank (PDB), operated by Rutgers, The State University of New Jersey; the San Diego Supercomputer Center at the University of California, San Diego; and the Center for Advanced Research in Biotechnology/UMBI/NIST, has 3-D structure of biological macromolecules.

Center for Disease Control is an excellent information about obesity and other health issues.

The Whole Brain Atlas contains detailed images of the human brain.

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