The liver isozyme of stearoyl-CoA desaturase (SCD1) is a critical target for altering lipoprotein secretion. Reducing SCD1 activity lowers the amounts of unhealthy triglycerides circulating throughout the body. Lam et al., (2007) recently found that increasing the amounts of glucose in the hypothalamus of the brain lowered the levels of circulating triglycerides in the blood. These results may lead to ways of reducing harmful levels of very-low density lipoproteins (VLDL). By determining a way to lower the activity of the fatty acid desaturase, there is the potential for the results of Lam et al., (2007) to translate into delaying or preventing the onset of human metabolic syndromes such as diabetes, obesity, and cardiovascular disease.