Novel Drug Design Strategies for the Treatment of Human African Trypanosomiasis

 

Glossary

(in alphabetical order)

 

ATP- Adenosine triphosphate. A molecule that provides chemical energy via donation of phosphate group donor to another molecule. The "energy currency" of the cell (Nelson et al., 2006).

catalytic mechanism- The sum total of the chemical steps involved in a reaction catalyzed by an enzyme (Purves et al. 2004).

crystal structure- The three-dimensional arrangement of all the atoms in a protein as determined by a technique called x-ray crystallography (Berg et al. 2005).

endemic- A disease present in a community at all times but in relatively low frequency (Purves et al. 2004).

eukaryotes- Organisms with a complex cell or cells, where the genetic material is organized into a membrane-bound nucleus or nuclei (Purves et al. 2004).

homologous- A similarity between two structures that is due to a common ancestor (Purves et al. 2004).

protozoa- Single-celled eukaryotes that have characteristics usually associated with animals, including mobility and heterotrophy (Purves et al. 2004).

pyrophosphate- A molecule that provides chemical energy via donation of phosphate group donor to another molecule. A highly unstable molecule that easily dissociates (Nelson et al., 2006).

rational drug design- The design of drug compounds based on a known protein structure (Nelson et al., 2006).

regulation- Describes the molecules and reactions that activate, inactivate, and control the concentration of a protein (Nelson et al., 2006).

subunit- A single polypeptide chain. Subunits can associate to form larger protein complexes (Nelson et al., 2006).