Figure 3. ASIC1 subunit interaction. The interactions between two adjacent subunits at three distinct points (indicated by the boxes) are shown. The top box shows the interaction of the α6 helix of one subunit’s knuckle subdomain with the concave surface on an adjacent subunit’s finger subdomain. The middle box shows the interaction of Arg716 with α5 helix of an adjacent subunit’s thumb subdomain and Lys212 with a buried chloride ion. The bottom box shows the interaction of Asp79 on one subunit and His74 and Gln421 on another subunit. PDB ascession code: 2QTS.