References on Recombination

BIOC/MCB 568 -- Fall 2010
John W. Little--University of Arizona

BIOC/MCB568 Home Page

 References

 

Reviews

Kowalczykowski, S.C., TIBS 25, 156-165 (2000). "Initiation of genetic recombination and recombination-dependent replication". Distributed in class.

Kreuzer, K., Annu. Rev. Microbiol. 59, 43-67 (2005). "Interplay between DNA replication and recombination in prokaryotes".

Heller, R.C. and Marians, K.J. Nat. Rev. Mol. Cell Biol. 7, 932-943 (2006). "Replisome assembly and the direct restart of stalled replication forks." Discusses diverse mechanisms for repairing and restarting stalled forks. (Reference is also in the list for DNA repair and mutagenesis).

Holliday junctions and resolvases

West, S.C. Cell 94, 699-701 (1998). "RuvA gets x-rayed on Holliday". Describes models for RuvAB action based on crystal structures.

Liu, Y. and West, S.C. Nat. Rev. Mol. Cell Biol. 5, 937-946 (2004). "Happy Hollidays: 40th anniversary of the Holliday junction."

Declais,A. and Lilley, D.M.J. Curr. Op. Struct. Biol. 18, 86-95 (2008). "New insight into the recognition of branched DNA structure by junction-resolving enzymes". Describes strcutures of HJ's and co-crystal structures with several resolvases.

Crystal structure of RecA

Chen, Z., Yang, H. and Pavletich, N.P. Nature 453, 489-496 (2008). "Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures". A real tour-de-force. The paper shows the structure of a RecA filament complexed with ssDNA, and a separate structure with duplex DNA. In the latter structure, one of the strands is in the same location as in the other structure, and the second strand is paired with the first one and hardly contacts RecA. If you want a PDB file of a longer filament, which I made from superimposing two of these structures, please ask me. I also have the RasMol scripts used in class.

Another link:

Link to a web page on the class site: "Interconversion of various forms of the Holliday junction, fork reassembly after fork hits a nick, DSB repair model, more on RecA. Relevant both to repair and to recombination.

Other types of recombination:

Grindley, N.D.F., Whiteson, K.L. and Rice, P.A, Annu. Rev. Biochem. 75, 567–605 (2006). "Mechanisms of site-specific recombination."

Jones, J.M. and Gellert, M. Immunol. Revs. 200, 233-248 (2004). "The taming of a transposon: V(D)J recombination and the immune system."

 Paper (for class)

Liu, J., Xu, L., Sandler, S.J. and Marians, K.J. PNAS 96, 3552-3555 (1999). "Replication fork assembly at recombination intermediates is required for bacterial growth." Distributed in class.