My research has focused on the role of metabolism in the conversion of natural, and xenobiotic, agents into mutagens and carcinogens. My colleagues and I were the first to define the unique processes through which plant systems use their unique biochemistry to metabolize agents into carcinogens that can affect humans, and my current research investigations are targeted towards gaining an understanding of the role of chronic inflammation in mammals and cancer causation.
Interview
Research Publications:
Kramers, P. G. N., J. M. Gentile, B. J. A. M. Gryseels, P. Jordan, N. Katz, K. E. Mott, J. J. Mulvihill, J. L. Seed and H. Frohberg. 1991. Schistosomiasis: A case study in the feasibility of mutation epidemiology, including a review of the genotoxicity and carcinogenicity of antischistosomal drugs. Mutation Res. 257:49-89.
Gentile, J. M. 1991. The role of genotoxins in parasite-associated cancer. Revista de Latinoamericana de Genetica 1:75-80.
Gentile, J. M., P. Johnson and S. Robbins. 1991. Activation of alfatoxin B1 and benzo(a)pyrene by tobacco cells in the plant cell/microbe coincubation assay, in J. W. Gorsuch (Ed.), Use of Plants in Toxicity Assessment, ASTM Press - Philadelphia . pp 318-325.
Gentile, J. M. and G. J. Gentile. 1991. The antimutagenic effect of chlorophyllin on 4-nitro-o-phenylenediamine: the balance between plant activation and deactivation. Mutation Res. 250:79-86.
Anwar, W., W. W. Au, A. Massoud, J. M. Gentile, and J. Ashby. 1992. Summary recommendations from the First International Conference on Environmental Mutagens in Human Populations at Risk: Cairo , 1992. Mutation Res. 260: 237-241.
Isola, V. J., T. C. Hartman, S. J. Trumble, M. C. Ruzek, and J. M. Gentile. 1993. Metabolism of 2-aminoflourene by human polymorphonuclear leukycytes: More evidence for the association between inflammation and cancer. Environmental Health Perspectives 101:27-31.
Ashby, J., W. Anwar, W. W. Au, A. Massoud, and J. M. Gentile. 1993. Genetic toxicology in developing countries: comments and recommendations. Environmental Health Perspectives 101:122-126.
Gentile, J. M. and G. J. Gentile. 1994. Implications for the involvement of the immune system in parasite-associated cancers. Mutation Res. 305:315-320.
Wilson, L., T. Williamson, J. Gronowski, G. J. Gentile, and J. M. Gentile. 1994. Mechanisms of action in the activation of 4-nitro-o-phenylenediamine by plant systems. Mutation Res. 307:185-192.
Gentile, J. M. 1994. Mechanisms of carcinogenicity in parasite-associated cancers. In IARC Monograph 61, Lyon . pp 121-175.
Gentile, J. M. and P.Ostrosky-Wegman. 1994. Parasite-Associated Cancers: Preface. Mutation Res. 305:117.
Gentile, J. M ., K. Sankaranarayanan, and P. H. Lohman. 1996. DNAging: Genetic instability and aging. Mutation Res. 316:5-6.
Te, C., J. M. Gentile, B. C. Baugley, A. E. Pearson, T. Gregory, and L. R. Ferguson. 1997. In vivo effects of chlorophyllin on the antitumor agent cyclophosphamide. Int. J. Cancer 70:84-89.
Rahimi, S., J. Zwiesler, R. Montero, G. J. Gentile, L. R. Ferguson, and J. M. Gentile. 1998. Effect of selected antimutagens on an array of antitumor agents. Mutation Res. 402:289-298.
Gentile, J. M., B. Nannenga, G. J. Gentile, and R. Montero. 1998. Enhanced liver cell mutations in trematode-infested Big Blue â Transgenic Mice. Mutation Research 400:355-360.
Montero, R., L. Frederick, G. Silva, J. McManus, T. Murphy, G. J. Gentile, H. Blankespoor, and J.M. Gentile. 1999. Selective expression of CYP2A5 enzymes in Fasciola hepatica-infected mice. Mutagenesis 14: 217-220
Mortona, O. H. Martin, G.J. Gentile and J.M. Gentile. 2002. Sequence specificity of parasite-induced mutations. Mutation Research , 484: 69-76.
Stowe, T., G.J. Gentile, and J.M. Gentile (2006). Sequence specificity in AFB1-induced mutations in F. hepatica-infected Big Blue® transgenic mice. Mutagenesis (submitted).
Science Education Publications:
Gentile, J. M . 1997. Looking to the Future: A need for scientists to take seriously the role of educator/mentor. Mutation Res. Forum 2: 1-3.
Gentile, J.M. 2000. Then and now: The Research-Integrated Educational Model at Hope College , in In Search of Academic Excellence: The Integral Role of Research in Undergraduate Education. M. Doyle, Ed. Research Corporation Press, pp. 79-86.
Gentile, J.M. 2001. Investing in faculty : the only way to sustain a successful academic enterprise. Academic Excellence Factbook, Research Corporation. Pp. 23-28.
Gentile, J.M. 2002. Building a new faculty : the development of leadership. In Leadership in Undergraduate Science Education, J. Narum, Ed. Josey-Bass , N.Y. , pp. 97-101.
Gentile, J.M. . 2002. Hope College : A vision for the future of science that can be built upon. In Tradelines, Steve Westfall, Ed., Tradelines Publicaitons, CA., pp, 1-12.
Wood, W., J.M. Gentile 2003 Teaching in a Research Context. Science. 302: 1510
Wood, W., J.M. Gentile 2003 The first National Academies Summer Institute for Undergraduate for Education in Biology. Cell Biology Education. 2: 207-209.
Kennedy, D. and J.M. Gentile. (2003). Is Biology 2010 the right blueprint for the biology of the future? Cell Biology Education 2: 224-227
Handlesman, J., D. Ebert-May, R. Beichnner, P. Bruns, A. Chang, R. DeHann , J. M. Gentile, S. Lauffer, J. Stewart, S.M. Tilghman, W. Wood 2004. Scientific Teaching) Science 304: 521-522.
Gentile, J.M. 2004. The hard road to education reform. Frontiers in Ecology and the Environment. 6: 283.
Cronkite, D., J.L. Andersen, J.M. Gentile (2005). An Integrating Culture of Undergraduate Research at Hope College . Reinvigorating theUndergraduate Experience: Successful Models Supported by the NSF RAIRE/AIRE Programs. L. Kauffman and J. Stocks, Eds. http://www.cur.org/publications/aire_raire/hope.asp
National Reports (Committee & Co-Author Responsibility
What Works: Building Natural Science Communities. A Plan for Strengthening Undergraduate Science and Mathematics. Volume 1. 1991. Stamates Communications, Inc. (Washington, DC). 100 pp.
What Works: Building Natural Science Communities: A Plan for Strengthening Undergraduate Science and Mathematics. Volume II. 1992. Stamates Communications, Inc. (Washington, DC) . 142 pp.
Transforming Undergraduate Education in Science, Mathematics and Technology. 1999. National Academy Press (Washington , DC). 113 pp.
Environmental Contamination, Biotechnology and the Law: The Impact of Emerging Genomic Information. 2001. National Academy Press (Washington , DC). 31 pp.
Stem Cells and the Future of Regenerative Medicine. 2002. National Academy Press (Washington , DC). 59 pp.
Scientific and Medical Aspects of Human Reproductive Cloning. 2002. National Academy Press (Washington, DC) 272 pp.
Biology 2010: A Reflection on the Undergraduate Biology Education for the Next Decade. 2002. National Academy Press (Washington , DC) 144 pp.
Predicting Invasions of Nonindigenous Plants and Plant Pests. 2002. National Academy Press (Washington , DC) 194 pp.
Animal Biothnology: Science-Based Concerns. 2002. National Academy Press (Washington, DC). 179 pp.
The National Plant Genome Initiative: Objectives for 2003-2008. National Academy Press (Washington , D.C.) 75 pp.
Sharing Publication-Related Data and Materials: Responsibilities of Authorship in the Life Sciences. 2003. National Academy Press (Washington , DC) 104 pp.
NEON: Addressing the Nation’s Environmental Challenges. 2003. National Academy Press (Washington , DC). 75 pp.
Biotechnology Research in the Age of Terrorism. 2004. National Academy of Sciences Press (Washington , DC). 147 pp.
Safety of Genetically Engineered Foods: Approaches to Assessing Unintended Health Effects. 2004. National Academy Press (Washington , DC). 235 pp.
Reopening Public Facilities After a Biological Attack: A Decision-Making Framework. 2005. National Academy Press (Washington , DC). 210 pp.
Guidelines for Human Embryonic Stem Cell Research. 2005. National Academy Press (Washington , DC). 166 pp.
Bridges to Independence : Fostering the Independence of New Investigators in Biomedical Research. 2005. National Academy Press (Washington , DC). 153 pp.
Communicating Toxicogenomics Information to Non-Experts. 2005. National Academy Press (Washington , DC). 48 pp.
Seeking Security: Pathogens, Open Access, and Genome Databases. 2005. National Academy Press (Washington , DC). 74 pp.
