Publications 2008

Matthew S. Dubrava, Wendy M. Ingram, Sue A. Roberts, Andrzej Weichsel, William R. Montfort, and Matthew H. J. Cordes .   N15 Cro and λ Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces, Protein Science (2008), 17 , 803-812.

Shane D. Morrison, Sue A. Roberts, Abreeza M. Zegeer, William R. Montfort, and Vahe Bandarian. A new use for a familiar fold: The x-ray crystal structure of GTP-bound GTP cyclohydrolase III from Methanocaldococcus jannaschii reveals a two metal ion catalytic mechanism.   Biochemistry (2008), 47, 230-242.

Hall, Branwen M., Roberts, Sue A., Heroux, Annie M., Cordes, Matthew H. Two structures of a  λ-Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA. J. Mol Biol . (2008), 375, 802-811.

Christian G. Roessler, Branwen M. Hall, William J. Anderson, Wendy M. Ingram, Sue A. Roberts, William R. Montfort, and Matthew H. J. Cordes.   Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds. PNAS , (2008), 105, 2343-2348.

Pete W. Dunten, Elizabeth J. Little, Mark T. Gregory, Veena M. Manohar, Michael Dalton, David Hough, Jurate Bitinaite, and Nancy C. Horton. The structure of SgrAI bound to DNA; recognition of an 8 base pair target. Nucl. Acids Res. 2008, 36, 5405-5416.

Babic AC, Little EJ, Manohar VM, Bitinaite J, Horton NC. DNA distortion and specificity in a sequence-specific endonuclease. J Mol Biol. 2008 383, 186-204.

James E. Spoonamore, Sue A. Roberts, Annie Heroux and Vahe Bandarian.   X-ray crystal structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor . Acta Crystallogr. F. (2008), F64, 875-879.

Publications 2007

Shokhireva TKh, Weichsel A, Smith KM, Berry RE, Shokhirev NV, Balfour CA, Zhang H, Montfort WR, Walker FA. Assignment of the Ferriheme Resonances of the Low-Spin Complexes of Nitrophorins 1 and 4 by 1H and 13C NMR Spectroscopy: Comparison to Structural Data Obtained from X-ray Crystallography. Inorganic Chemistry, (2007), 46, 2041-2056.

Isabell R. Loftin, Sylvia Franke, Ninian J. Blackburn, and Megan M. McEvoy. Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X-ray absorption spectroscopy Protein Sci, (2007), 16, 2287-2293.

Schreiter ER, Rodríguez MM, Weichsel A, Montfort WR, Bonaventura J. S-nitrosylation-induced conformational change in blackfin tuna myoglobin. J. Biol. Chem., (2007), 282, 19773-80.

Weichsel, A., Brailey, JL, Montfort, WR. Buried S-Nitrosocysteine Revealed in Crystal Structures of Human Thioredoxin. Biochemistry, (2007), 46, 1219-1227.

Earlier Publications

Roberts SA, Hyatt, DC, Honts, JE, Changchien C, Maley, GF, Maley F, Montfort WR. Y94F Mutant of E. coli Thymidylate S ynthase. Acta Crystallogr F62 (2006), 840-843.

Segal DJ, Crotty JW, Bhakta MS, Barbas CF, Horton NC. Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol. (2006), 363, 405-21.

Joshi HK, Etzkorn C, Chatwell L, Bitinaite J, Horton NC. Alteration of sequence specificity of the type II restriction endonuclease HincII through an indirect readout mechanism. J Biol Chem. (2006) 281,23852-69.

Weichsel A, Maes EM, Andersen JF, Valenzuela JG, Shokhireva, TK, Walker FA, and Montfort WR. Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein. Proc. Natl. Acad. Sci. USA, (2005), 102, 594-599.

Maes EM, Roberts SA, Weichsel A, Montfort WR. Heme Distortion in Nitrophorin 4: Ultra-High Resolution Structures of Ferrous Complexes. Biochemistry, (2005), 44,12690-12699.

Loftin IR, Franke S, Roberts SA, Weichsel A, Heroux A, Montfort WR, Rensing C, McEvoy M. A Novel Copper-binding Fold for the Periplasmic Metallochaperone Cusf. Biochemistry, (2005), 44, 10533-10540.

Berry RE, Ding XD, Shokhireva TK, Weichsel A, Montfort WR, Walker FA. Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4. J Biol Inorg Chem. (2004), 9, 135-144.

Maes EM, Weichsel A, Andersen JF, Shepley D, Montfort WR. Role of Binding Site Loops in Controlling Nitric Oxide Release: Structure and Kinetics of Mutant Forms of Nitrophorin 4. Biochemistry (2004), 43, 6679-6690.

Kondrashov DA, Roberts SA, Weichsel A, Montfort WR. Protein functional cycle viewed at atomic resolution: conformational change and mobility in nitrophorin 4 as a function of pH and NO binding. Biochemistry (2004), 43, 13637-13647.

K. Nienhaus, E. M. Maes, A. Weichsel, W. R. Montfort and G. U. Nienhaus, Structural dynamics controls nitric oxide affinity in Nitrophorin 4 Journal of Biological Chemistry, (2004) 279, 39401-39407.

Roberts, Sue A.; Wildner, Guenter F.; Grass, Gregor; Weichsel, Andrzej; Ambrus, Attila; Rensing, Christopher; Montfort, William R. A Labile Regulatory Copper Ion Lies Near the T1 Copper Site in the Multicopper Oxidase CueO. J.Biol.Chem. (2003), 278, 31958-31963.

Roberts, Sue A.; Weichsel, Andrzej; Grass, Gregor; Thakali, Keshari; Hazzard, James T.; Tollin, Gordon; Rensing, Christopher; Montfort, William R. Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli. PNAS (2002), 99, 2766-2771.

Roberts, Sue A.; Weichsel, Andrzej; Qiu, Yan; Shelnutt, John A.; Walker, F. Ann; Montfort, William R. Ligand-Induced Heme Ruffling and Bent NO Geometry in Ultra-High-Resolution Structures of Nitrophorin 4. Biochemistry (2001), 40, 11327-11337.

Weichsel, Andrzej; Andersen, John F.; Roberts, Sue A.; Montfort, William R. Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial. Nature Struct Biol. (2000), 7, 551-554.